spectrum collection small-molecule compound library Search Results


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small molecule compound collection  (Evotec Inc)
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Overview of small <t>molecule</t> <t>screen</t> for regulators of axon degeneration. A, Compounds selected for the screen. Emergent self-organizing maps (SOM) obtained for the MDDR <t>collection</t> and the Evotec known drugs and bioactives. Each dot corresponds to a <t>compound.</t> X-SOM and Y-SOM correspond to the X and Y direction of the calculated self-organizing map. The distance between dots is an expression of structural similarity between compounds. Green dots represent molecules from the MDDR classified launched drugs while gray dots represent the remainder from the MDDR collection (221,055 compounds total). Blue dots represent the 871 compounds screened that consist of known drugs as well as additional compounds with known bioactivity (CSB ACL collection). B, Scatter plot showing results from primary DRG screen. Compound plates were screened at 20 μm in duplicate and a correlation of the respective percentage neuroprotection values is shown. The R2 value of the replicate data points was 0.57. The mean Z′ value of the screening plates was 0.61. Hits (blue squares) versus nonhits (red squares) were qualified based on the hit threshold of 25% protection. Compounds reducing nuclei number <70% of NGF control were defined as cytotoxic (X shaped) and excluded from the hit set. Forty-two compounds fulfilled these hit criteria. C, Example of results from primary DRG screen. A screening plate is shown as a heat map indicating axonal protection in shades of green color (top). High (positive) controls (H; 100%) are NGF wells located in column 24, and low (negative) controls (L; 0%) are anti-NGF wells located in column 23. A neuroprotective compound served as a quality control (C). Representative primary data from the screen with Tuj1 in green and DRAQ5 in red. Some wells have a degree of Tuj1 staining indicating protection of axons while others do not. Scale bar, 50 μm.
Small Molecule Compound Collection, supplied by Evotec Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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bioactive screening library  (Selleck Chemicals)
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Overview of small <t>molecule</t> <t>screen</t> for regulators of axon degeneration. A, Compounds selected for the screen. Emergent self-organizing maps (SOM) obtained for the MDDR <t>collection</t> and the Evotec known drugs and bioactives. Each dot corresponds to a <t>compound.</t> X-SOM and Y-SOM correspond to the X and Y direction of the calculated self-organizing map. The distance between dots is an expression of structural similarity between compounds. Green dots represent molecules from the MDDR classified launched drugs while gray dots represent the remainder from the MDDR collection (221,055 compounds total). Blue dots represent the 871 compounds screened that consist of known drugs as well as additional compounds with known bioactivity (CSB ACL collection). B, Scatter plot showing results from primary DRG screen. Compound plates were screened at 20 μm in duplicate and a correlation of the respective percentage neuroprotection values is shown. The R2 value of the replicate data points was 0.57. The mean Z′ value of the screening plates was 0.61. Hits (blue squares) versus nonhits (red squares) were qualified based on the hit threshold of 25% protection. Compounds reducing nuclei number <70% of NGF control were defined as cytotoxic (X shaped) and excluded from the hit set. Forty-two compounds fulfilled these hit criteria. C, Example of results from primary DRG screen. A screening plate is shown as a heat map indicating axonal protection in shades of green color (top). High (positive) controls (H; 100%) are NGF wells located in column 24, and low (negative) controls (L; 0%) are anti-NGF wells located in column 23. A neuroprotective compound served as a quality control (C). Representative primary data from the screen with Tuj1 in green and DRAQ5 in red. Some wells have a degree of Tuj1 staining indicating protection of axons while others do not. Scale bar, 50 μm.
Bioactive Screening Library, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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∼3-million-compound small-molecule library  (Genentech inc)
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Overview of small <t>molecule</t> <t>screen</t> for regulators of axon degeneration. A, Compounds selected for the screen. Emergent self-organizing maps (SOM) obtained for the MDDR <t>collection</t> and the Evotec known drugs and bioactives. Each dot corresponds to a <t>compound.</t> X-SOM and Y-SOM correspond to the X and Y direction of the calculated self-organizing map. The distance between dots is an expression of structural similarity between compounds. Green dots represent molecules from the MDDR classified launched drugs while gray dots represent the remainder from the MDDR collection (221,055 compounds total). Blue dots represent the 871 compounds screened that consist of known drugs as well as additional compounds with known bioactivity (CSB ACL collection). B, Scatter plot showing results from primary DRG screen. Compound plates were screened at 20 μm in duplicate and a correlation of the respective percentage neuroprotection values is shown. The R2 value of the replicate data points was 0.57. The mean Z′ value of the screening plates was 0.61. Hits (blue squares) versus nonhits (red squares) were qualified based on the hit threshold of 25% protection. Compounds reducing nuclei number <70% of NGF control were defined as cytotoxic (X shaped) and excluded from the hit set. Forty-two compounds fulfilled these hit criteria. C, Example of results from primary DRG screen. A screening plate is shown as a heat map indicating axonal protection in shades of green color (top). High (positive) controls (H; 100%) are NGF wells located in column 24, and low (negative) controls (L; 0%) are anti-NGF wells located in column 23. A neuroprotective compound served as a quality control (C). Representative primary data from the screen with Tuj1 in green and DRAQ5 in red. Some wells have a degree of Tuj1 staining indicating protection of axons while others do not. Scale bar, 50 μm.
∼3 Million Compound Small Molecule Library, supplied by Genentech inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Overview of small molecule screen for regulators of axon degeneration. A, Compounds selected for the screen. Emergent self-organizing maps (SOM) obtained for the MDDR collection and the Evotec known drugs and bioactives. Each dot corresponds to a compound. X-SOM and Y-SOM correspond to the X and Y direction of the calculated self-organizing map. The distance between dots is an expression of structural similarity between compounds. Green dots represent molecules from the MDDR classified launched drugs while gray dots represent the remainder from the MDDR collection (221,055 compounds total). Blue dots represent the 871 compounds screened that consist of known drugs as well as additional compounds with known bioactivity (CSB ACL collection). B, Scatter plot showing results from primary DRG screen. Compound plates were screened at 20 μm in duplicate and a correlation of the respective percentage neuroprotection values is shown. The R2 value of the replicate data points was 0.57. The mean Z′ value of the screening plates was 0.61. Hits (blue squares) versus nonhits (red squares) were qualified based on the hit threshold of 25% protection. Compounds reducing nuclei number <70% of NGF control were defined as cytotoxic (X shaped) and excluded from the hit set. Forty-two compounds fulfilled these hit criteria. C, Example of results from primary DRG screen. A screening plate is shown as a heat map indicating axonal protection in shades of green color (top). High (positive) controls (H; 100%) are NGF wells located in column 24, and low (negative) controls (L; 0%) are anti-NGF wells located in column 23. A neuroprotective compound served as a quality control (C). Representative primary data from the screen with Tuj1 in green and DRAQ5 in red. Some wells have a degree of Tuj1 staining indicating protection of axons while others do not. Scale bar, 50 μm.

Journal: The Journal of Neuroscience

Article Title: Identification of 12/15-Lipoxygenase as a Regulator of Axon Degeneration through High-Content Screening

doi: 10.1523/JNEUROSCI.2936-14.2015

Figure Lengend Snippet: Overview of small molecule screen for regulators of axon degeneration. A, Compounds selected for the screen. Emergent self-organizing maps (SOM) obtained for the MDDR collection and the Evotec known drugs and bioactives. Each dot corresponds to a compound. X-SOM and Y-SOM correspond to the X and Y direction of the calculated self-organizing map. The distance between dots is an expression of structural similarity between compounds. Green dots represent molecules from the MDDR classified launched drugs while gray dots represent the remainder from the MDDR collection (221,055 compounds total). Blue dots represent the 871 compounds screened that consist of known drugs as well as additional compounds with known bioactivity (CSB ACL collection). B, Scatter plot showing results from primary DRG screen. Compound plates were screened at 20 μm in duplicate and a correlation of the respective percentage neuroprotection values is shown. The R2 value of the replicate data points was 0.57. The mean Z′ value of the screening plates was 0.61. Hits (blue squares) versus nonhits (red squares) were qualified based on the hit threshold of 25% protection. Compounds reducing nuclei number <70% of NGF control were defined as cytotoxic (X shaped) and excluded from the hit set. Forty-two compounds fulfilled these hit criteria. C, Example of results from primary DRG screen. A screening plate is shown as a heat map indicating axonal protection in shades of green color (top). High (positive) controls (H; 100%) are NGF wells located in column 24, and low (negative) controls (L; 0%) are anti-NGF wells located in column 23. A neuroprotective compound served as a quality control (C). Representative primary data from the screen with Tuj1 in green and DRAQ5 in red. Some wells have a degree of Tuj1 staining indicating protection of axons while others do not. Scale bar, 50 μm.

Article Snippet: The time course of degeneration following withdrawal of NGF differs somewhat due to assay setup and species of DRG neurons used. . Small molecule handling and NGF withdrawal The small molecule compound collection screen consisted of Evotec's CSB ACL collection of 292 manually selected bioactives and known drugs as well as an additional set of 579 selected known drugs (a total of 871 compounds).

Techniques: Expressing, Control, Staining